William Byron may refer to:

• William Byron, 3rd Baron Byron (1636–1695), British peer and great-great-grandfather of poet George Gordon Byron
• William Byron, 4th Baron Byron (1669–1736), British peer and great-grandfather of poet George Gordon Byron
• William Byron, 5th Baron Byron (1722–1798), British peer and great-uncle of poet George Gordon Byron
• William D. Byron (1895–1941), Democratic member of U.S. Congress 1939–1941 from Maryland's 6th congressional district
• William Byron (racing driver) (born 1997), American race car driver
• William J. Byron (1927–2024), priest of the Society of Jesus
• Lord Byron (umpire) (1872–1955), American baseball umpire
• William Byron (MP) (1749–1776), British politician

• William Byron Rumford (1908–1986), California legislator

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