William Hopkins (1793–1866) was an English mathematician and geologist.

William Hopkins may also refer to:

• Bill Hopkins (Australian footballer) (born 1936), Australian rules footballer
• William Hopkins (architect) (1820–1901), architect to the Diocese of Worcester, England
• William Hopkins (Bewdley MP) (died 1647), English politician who won election to the House of Commons in 1647
• William Hopkins (Canadian politician) (1864–1935), hardware merchant and political figure in Saskatchewan, Canada
• Bill Hopkins (composer) (1943–1981), British composer, pianist and critic
• William Hopkins (footballer, born 1871) (1871-?), English footballer, played for Derby County and Ardwick
• Bill Hopkins (footballer, born 1888) (1888–1938), English footballer
• Bill Hopkins (novelist) (1928–2011), British author
• William Hopkins (speaker) (1647–1723), politician from Rhode Island
• William B. Hopkins (1922–2012), American politician
• William B. Hopkins (Maryland politician) (died 1909), American politician
• William Hersey Hopkins (1841–1919), American academic and college administrator
• William J. Hopkins (civil servant) (1910–2004), American civil servant
• William R. Hopkins (1869–1961), city manager of Cleveland, Ohio

• William E. Hopkin (died 1953), Welsh trade union leader

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