The Textilease/Medique 300 was a NASCAR Busch Series stock car race held at South Boston Speedway, in South Boston, Virginia. One of the inaugural events of the series from its 1982 season, it was one of three races at the track in 1982, five in 1983, three in 1984 to 1985, four in 1986 and, from 1987 to 1991, was the series' second annual visit to the track; no Busch Series events were held at South Boston Speedway in 1992 or 1993, during which time the track was reconfigured from 0.357 mi (0.575 km) to 0.400 mi (0.644 km) in length, but in 1994 a single race returned to the track,^[1] and was run annually until 2000, after which South Boston Speedway departed the series schedule.^[2] The race distance was 200 laps (71.4 miles (114.9 km)) in 1982 and from 1985 to 1990, 300 laps (107.1 miles (172.4 km)) from 1983 to 1984 and in 1991, and 300 laps (120 miles (193.1 km)) from 1994 to 2000.^[2]

Tommy Houston won the race three times, the most of any driver; Dennis Setzer scored his first career Busch Series victory in the 1994 event.^[1]