1-Deoxy-D-xylulose_5-phosphate

1-Deoxy-<small>D</small>-xylulose 5-phosphate

1-Deoxy-D-xylulose 5-phosphate

Chemical compound


1-Deoxy-d-xylulose 5-phosphate is a biosynthetic intermediate in the non-mevalonate pathway.[1]

Quick Facts Names, Identifiers ...

Function

The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is DXP synthase.[2] The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP.[2][3] In addition, the molecule is involved in making thiamine (Vitamin B1) and pyridoxol (Vitamin B6).[2]

The non-mevalonate pathway intermediate 1-deoxy-d-xylulose 5-phosphate (DXP) also acts as a precursor in making isoprenoids in many species such as bacteria, plants, and apicomplexan parasites, contributing to biological diversity.[1]


References

  1. Bartee D, Freel Meyers CL (October 2018). "Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism". Accounts of Chemical Research. 51 (10): 2546–2555. doi:10.1021/acs.accounts.8b00321. PMC 6309272. PMID 30203647.
  2. Xiang S, Usunow G, Lange G, Busch M, Tong L (January 2007). "Crystal Structure of 1-Deoxy-d-xylulose 5-Phosphate Synthase, a Crucial Enzyme for Isoprenoids Biosynthesis". Journal of Biological Chemistry. 282 (4): 2676–2682. doi:10.1074/jbc.M610235200.

See also


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