The 28th Annual Screen Actors Guild Awards, honoring the best achievements in film and television performances for the year 2021, was presented on February 27, 2022 at the Barker Hangar in Santa Monica, California.^[1][2][3][4] The ceremony was broadcast live on both TNT and TBS 8:00 p.m. EST / 5:00 p.m. PST. The nominees were announced on January 12, 2022 by Rosario Dawson and Vanessa Hudgens via Instagram Live.^[5]

For film, the deaf/non-hearing cast members that are a part of the ensemble of CODA made history by becoming the first disabled performers to receive a nomination for Outstanding Performance by a Cast in a Motion Picture in the awards' history. Individually for CODA, Troy Kotsur became the first deaf/non-hearing actor to receive an individual SAG Award nomination. For television, Squid Game made history by becoming the first non-English series and first Korean series to be nominated for Outstanding Performance by an Ensemble in a Drama Series. Individually for Squid Game, Lee Jung-jae became the first male actor from Asia and Korea to receive an individual SAG Award nomination and HoYeon Jung became the second actress of Asian as well as Korean descent to do the same.^[6] With their respective portrayals of Aretha Franklin in the film Respect and television miniseries Genius: Aretha, Jennifer Hudson and Cynthia Erivo became the first set of actors to be nominated for playing the same role in the same year.^[7] For her performance as Anita in Steven Spielberg's West Side Story, Ariana DeBose became the first Afro-Latina and openly queer woman of color to win the Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Supporting Role.

Helen Mirren was announced as the 2021 SAG Life Achievement Award recipient on November 18, 2021.^[8]

• Note: Winners are listed first and highlighted in boldface.

The segment, introduced by Maggie Gyllenhaal, was set to the song "Sailboat" by Cody Fry and Ben Rector, and honored the following who died in 2021 and early 2022:^[9][10]