6-Hydroxyflavone

6-Hydroxyflavone

6-Hydroxyflavone

Chemical compound

6-Hydroxyflavone is a flavone, a type of chemical compound. It is one of the noncompetitive inhibitors of cytochrome P450 2C9. It is reported in Crocus and leaves of Barleria prionitis Linn. (a common Acanthaceae from India).[1] 6-Hydroxyflavone shows anxiolytic activity in a mouse model.[2] Compared to the full agonist diazepam, 6-hydroxyflavone was approximately 200 times less potent.[2]

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References

  1. [1]
    M Daniel (2006). Medicinal Plants: Chemistry and Properties. Science Publishers. p. 78. ISBN 978-1-57808-395-4.
  2. [2]
    Ren, Lihuan; Wang, Feng; Xu, Zhiwen; Chan, Wing Man; Zhao, Cunyou; Xue, Hong (2010), "GABAA receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone", Biochemical Pharmacology, 79 (9): 1337–1344, doi:10.1016/j.bcp.2009.12.024, PMID 20067772


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