Chersiphron (/ˈkɜːrsɪfrɒn/; Greek: Χερσίφρων; fl. 6th century BC), an architect of Knossos in ancient Crete, was the builder of the Temple of Artemis at Ephesus, on the Ionian coast.^[1] The original temple was destroyed in the 7th century BC, and about 550 BC Chersiphron and his son Metagenes began a new temple, the Artemision, which became one of the Seven Wonders of the Ancient World in each of its three manifestations. It was burned by Herostratus in July 356 BC^{[1][n 1]} and rebuilt again.

The architect's name is recalled in Vitruvius, and in a passage of Pliny as "Ctesiphon", perhaps in confusion with the great Parthian city of the same name on the river Tigris.