Chronotherapy, also called chronotherapeutics^[1] or chronotherapeutic drug delivery,^[2] refers to the coordination of therapeutic treatments with an individual's circadian or other rhythmic cycles. This may be done to maximize effectiveness of a specific treatment, minimize possible side effects, or both.^[3][4]

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In the treatment of psychiatric conditions including bipolar depression,^[5][6] a form of chronotherapy combining intermittent sleep deprivation and morning bright light has shown efficacy and relative tolerability in a number of controlled studies.^[7][8][9]

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