DNA2L

DNA2L

DNA2L

Protein-coding gene in the species Homo sapiens

DNA2-like helicase is an enzyme that in humans is encoded by the DNA2 gene.[5][6][7] Dna2, a homolog of DNA2KL present in budding yeast, possesses both helicase and nuclease activity, with which it helps catalyze early steps in homologous recombination.[8]

Quick Facts DNA2, Available structures ...

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000138346 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000036875 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, Shibata T, Murakami Y, Hanaoka F (Mar 1997). "Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1". Genomics. 37 (3): 408–10. doi:10.1006/geno.1996.0581. PMID 8938459.
  6. [6]
    Masuda-Sasa T, Polaczek P, Campbell JL (Dec 2006). "Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation". J Biol Chem. 281 (50): 38555–64. doi:10.1074/jbc.M604925200. PMID 17032657.
  7. [7]
    "Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast)".
  8. [8]
    Mimitou, EP; Symington, LS (May 2009). "Nucleases and helicases take center stage in homologous recombination". Trends in Biochemical Sciences. 34 (5): 264–272. doi:10.1016/j.tibs.2009.01.010. PMID 19375328.

Further reading


Stub icon

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article DNA2L, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.