Diaminopyrimidine

Diaminopyrimidine

Diaminopyrimidine

Class of organic chemical compounds

Diaminopyrimidines (DAP) are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.

Iclaprim
Trimethoprim

They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim[1] and the antibiotics Iclaprim and trimethoprim).

Some have been patented as anti-cancer drugs.[2]

See also

References

  1. [1]
    http://aac.asm.org/cgi/content/full/45/12/3293 Archived 2008-08-29 at the Wayback Machine "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001
  2. [2]
    "Archived copy". Archived from the original on 2011-06-05. Retrieved 2009-01-05.{{cite web}}: CS1 maint: archived copy as title (link)


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