2005–06: Entry to the TV scene

In 2005, Chen began her professional acting career when she signed an 8-year contract with TVB. She started out as a host on numerous variety shows on TVB's Mandarin channel TVB8, before making her acting debut in the TVB series Forensic Heroes guest starring as a murderess.

2007–09: Breakthrough

In 2007, after starring in Heart of Greed, The Family Link, and Steps, Chen won her first acting award in the Best Supporting Actress category for her role in Steps.^[4] Additionally, she was also nominated for "My Favorite Female Character" and "Most Improved Actress" categories for the same role. She also received a nomination in the "Most Improved Actress" category for her roles in Heart of Greed and The Family Link in 2007.

Chen's breakthrough came in 2008, when her notable work was for the character of Gam Wing Hing (a mute girl) in TVB series Moonlight Resonance, an indirect sequel to Heart of Greed, as she had to learn sign language for the role.^[4][8][9] The role landed her nominations in the "Best Supporting Actress" and "My Favorite Female Character" categories for the second year in a row.

In 2009, Chen was nominated again for the "Best Supporting Actress" and "My Favorite Female Character" categories for her role in The Stew of Life.

2010–13: Leading roles and entry to the music scene

In 2010, Chen was cast in TVB's grand production series No Regrets as second female lead, securing her position as one of Hong Kong's celebrated new actresses, alongside Tavia Yeung, Linda Chung, Myolie Wu, and Kate Tsui. The role won her the Best Supporting Actress Award at the TVB Anniversary Awards and Best Actress in a Supporting Role at the 16th Asian Television Awards.

She later took on roles as the first female lead in productions including Lives of Omission, Queens of Diamonds and Hearts, and Triumph in the Skies II. Lives of Omission (2011) was a distant sequel to the 2009 film Turning Point in which Chen had also acted in as the sister of a triad boss. Queens of Diamonds and Hearts (2012) allowed Chen to experiment with looking 'ugly' on screen as her character Chung Mo Yim, based on historical figure Zhongli Chun, was born with a prominent birth mark on her face. Chen played the role of Holiday Ho in Triumph in the Skies II —a free-spirited punk girl who aspires to fly—who became emotionally entangled between two male leads, Captain Samuel Tong played by Francis Ng and Captain Jayden Koo played by Julian Cheung. Chen also starred in 2013's Will Power alongside veteran actors Wayne Lai and Moses Chan where she played the role of Sam Yuet Kan, a junior barrister with a tough personality.

Her contract with TVB ended in mid 2013 and Chen became a self-managed artiste. Having more freedom to choose and ever so determined to become a better actress, Chen would like to direct her focus on filming more movies and dramas, and she is not afraid to take up new challenges.

2014: Entry into China's TV industry

Chen acted in her first mainland Chinese drama series, Sound of the Desert, where she played the role of Li Yan.^[2] It aired in 2014 and was based on the historical romance novel Ballad of the Desert by Tong Hua.

2019: Entry into the US TV industry

Shortly after graduating from the Juilliard School, Chen was cast as Jolene in The Undoing alongside Nicole Kidman and Hugh Grant.

2009: Newcomer

In 2009, Chen took her chance at her first female lead role in the movie Turning Point as Michael Tse's girlfriend and Francis Ng's sister. Turning Point is a spin-off from the 2009 TVB crime drama E.U., where the character "Laughing Gor", played by Michael Tse, became a household name.

Chen was nominated for the Best New Performer category at the 29th Hong Kong Film Awards for her role in Turning Point.

2010–13: Budding film actress

In 2010, Chen starred in two movies, Black Ransom and 72 Tenants of Prosperity. In Black Ransom, she acted as a superintendent, alongside internationally acclaimed Hong Kong actor and film producer, Simon Yam. 72 Tenants of Prosperity on the other hand, was a light-hearted Hong Kong comedy film directed by Eric Tsang, involving a star-studded cast of Hong Kong stars.

Chen took to the movie scene again in 2011, acting in the first installment of the heartwarming I Love Hong Kong film series, directed and produced by Eric Tsang. She too worked together with Eric Tsang again who produced and acted in The Fortune Buddies, another Hong Kong comedy film which also co-stars Louis Yuen, Wong Cho-lam and Johnson Lee who are better known as "Fuk Luk Sau" (福祿壽).

Tales from the Dark 2 (2013) was her first shot at the horror movie scene, and acting with her is Gordon Lam. Chen's story revolves around pillow demons, where her character Chow Jing Ee is seen to suffer from serious insomnia after her break-up with her boyfriend Yuen Hao Hong, played by Gordon Lam. Chen delivered a stellar performance, and was commended for the preparation work she did prior to filming, by staying a few nights alone in the cold apartment they filmed at to get into character and understand the loneliness and insomnia that the character suffered. The media had focused on the scene where Chen's character accidentally killed her boyfriend and tried to get rid of the corpse by taking off all of his garments and putting him into a vacuum bag. This is the first time that Gordon Lam has gone fully nude in a film. Owing to the explicit scenes, the movie has received a Category III rating.^[10]

Chen starred in the Cantonese version of Despicable Me 3 as the voice of Lucy Wilde, an Anti-Villain League agent, Gru's wife and the girls' adoptive mother. Doing voiceover for an animation film for the first time, Chen commented that it requires a lot of energy and precision to sync with the character's lip movement and it takes capturing the unique sounds and myriad of nuances in personality to bring the character to life.

2015: Movies Pending Release

Chen concluded filming for The Treasure, directed by Gordon Chan and Ronald Tsang.

2021: US feature debut

Chen made her US film debut after being cast in the Marvel Cinematic Universe feature film Shang-Chi and the Legend of the Ten Rings as Ying Li.^[11][12][13] The movie is directed by Destin Daniel Cretton, and opened in theaters on 3 September 2021.^[14]

2013–16: Stage Debut

Ever since Chen's contract with Television Broadcasts Limited (TVB) concluded in 2013, she went on to pursue a 4-year Master of Fine Arts in Drama (MFA) Program at Juilliard School with the passion and determination to better herself as a professional artiste. The MFA Program only accepts 8 to 10 students each year, and encompasses areas such as production, directing, playwriting, pedagogy, and current trends in American and World Theater.

Chen's debut on the theatre stage came in 2016 with Skylight – the premiere of Chinese adaptation of the 1995 British play written by David Hare that debuted in West End and Broadway. The play was scheduled to run for 24 shows at the Hong Kong Academy for Performing Arts, but due to overwhelming responses, 11 additional shows were added, making that a total of 35 shows running across 1 July 2016 to 14 August 2016. Starring alongside Dayo Wong and Terrance Lau, Skylight was a sold-out show within a few hours, and it received plenty of raving positive reviews including praises for Chen's performance as a theatre actor.

2012: First album – Beautiful Life

In 2010, Chen signed under Stars Shine International and subsequently launched her first Canto-pop debut album, Beautiful Life, released on 31 July 2012. Some of the highlights from the album are "一半", "愛上鳥", and "Beautiful Life". Among these songs, "一半" was the first plugged song which garnered her awards in the Best Newcomer category across various music platforms such as 2012 TVB8 Golden Music Awards for the Bronze Award, 2012 Jade Solid Gold Best Ten Music Awards Presentation, and "2013 IFPI Hong Kong Top Sales Music Awards".

Within a week from the launch of her album, it had climbed up to first place on HMV's 'Asian Album Top Sales Chart'.^{[citation needed]}

Her contract with Stars Shine International ended in 2012.