Gadoxetic acid is a gadolinium-based MRI contrast agent.^[3] Its salt, gadoxetate disodium, is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals.^[1][4]

Quick Facts Clinical data, Trade names ...

Gadoxetic acid

Clinical data
Trade names	Eovist
Other names	Gadoxetate disodium (USAN US)
AHFS/Drugs.com	International Drug Names
ATC code	V08CA10 (WHO)
Legal status
Legal status	US: ℞-only[1] EU: Rx-only[2]
Identifiers
IUPAC name 2-[[2-[bis(2-oxido-2-oxoethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate; gadolinium(+3) cation
CAS Number	135326-11-3 Y
PubChem CID	131704314
DrugBank	DB08884 Y
ChemSpider	189907
UNII	3QJA87N40S
KEGG	D08008 Y D04288
ChEMBL	ChEMBL1201768 N
CompTox Dashboard (EPA)	DTXSID90928961
Chemical and physical data
Formula	C23H30GdN3O11
Molar mass	681.75 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOc1ccc(cc1)C[C@@H](CN(CCN(CC(=O)O)CC(=O)[O-])CC(=O)[O-])N(CC(=O)O)CC(=O)[O-].[Gd+3]
InChI InChI=1S/C23H33N3O11.Gd/c1-2-37-18-5-3-16(4-6-18)9-17(26(14-22(33)34)15-23(35)36)10-24(11-19(27)28)7-8-25(12-20(29)30)13-21(31)32;/h3-6,17H,2,7-15H2,1H3,(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H,35,36);/q;+3/p-3/t17-;/m0./s1 Key:PCZHWPSNPWAQNF-LMOVPXPDSA-K
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It is used to increase the T1 signal intensity while imaging the liver lesions such as benign cysts, hemangioma, and liver cancer. It is excreted into bile by active secretion.^[5]

In those with end-stage renal failure, the clearance rate is only 17% with terminal half-life of 12 times longer than those with normal renal function.^[5]