Born as Georgi Ivanov Cherkelov on 25 June 1930, in the city of Haskovo, Bulgaria, he initially began studying law at the Sofia University, where he remained for three years before transferring to the National Academy for Theater and Film ВИТИЗ Кръстьо Сарафов where he graduated in 1956. Cherkelov started his stage career in the Vratsa theater. His film debut was in the 1961 film The Last Round. During the fifty years of his career, he has appeared in more than 100 roles on stage and in about 70 films. While continuing to perform on the stage of the National Theater Ivan Vazov where he has worked for decades, Cherkelov was also the artistic director of the Ivan Radoev Dramatic Theatre in Pleven (1985–1990).
Georgi Cherkelov was one of the most prominent Shakespearean actors in Bulgaria, with memorable performances as King Lear, Richard II, Mercutio, Banco and many other major roles. He has played almost the entire repertoire of the British bard – a privilege many actors dream of, but only a few are given. Cherkelov's style was intelligent, with expressions based on subtle nuances, heavy pauses and solidly spoken phrases. His trademark were inborn dignity, loaded calm and incredible presence – unique personal characteristics of this great actor, which he infused into the characters he played.
In addition to being an extraordinary actor, Georgi Cherkelov has also staged a number of plays. Among the plays he directed are "One Flew Over the Cuckoo's Nest" (1982), "Wrestlers" (1981), "Huckleberry Finn" (1985), "Catcher in the Rye" (1998). Some of the adaptations for these plays he had written himself. In 2010 his book "Stories and emails" was published by Locus Publishing.
He died on 19 February 2012.