Glycine_reuptake_inhibitor

Glycine reuptake inhibitor

Glycine reuptake inhibitor

Add article description

A glycine reuptake inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters (GlyTs). Examples of GRIs include bitopertin (RG1678), Org 24598, Org 25935, ALX-5407, and sarcosine, which are selective GlyT1 blockers, and Org 25543 and N-arachidonylglycine, which are selective GlyT2 blockers.[1][2] Some weak and/or non-selective GlyT blockers include amoxapine and ethanol (alcohol).[3]

See also

References

  1. [1]
    Harsing LG, Juranyi Z, Gacsalyi I, Tapolcsanyi P, Czompa A, Matyus P (2006). "Glycine transporter type-1 and its inhibitors". Curr. Med. Chem. 13 (9): 1017–44. doi:10.2174/092986706776360932. PMID 16611082.
  2. [2]
    Harvey RJ, Yee BK (November 2013). "Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain". Nat Rev Drug Discov. 12 (11): 866–85. doi:10.1038/nrd3893. PMID 24172334. S2CID 28022131.
  3. [3]
    Harald Sitte, Michael Freissmuth (2 August 2006). Neurotransmitter Transporters. Springer Science & Business Media. pp. 472–. ISBN 978-3-540-29784-0.



Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article Glycine_reuptake_inhibitor, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.