1950s

• Cerebex (1953)
• Brainiac from the Superman comics (1958)

1960s

• Ultron from the Avengers (1968)

1990s

• LYLA, short for LYrate Lifeform Approximation from the Spider-Man 2099 comics (1992)
• Mr. Smartie, a teacher for Astra Furst (1995)

2000s

• Terror 2000 on Terra Obscura (2001)
• Multiple from the Schlock Mercenary webcomic (2000-2020), with Ennesby and Post-Dated Check Loan ("Petey") being some of the most prominent ones.

2010s

• Multiple from The True Lives of the Fabulous Killjoys comic series (2013-2014) by Gerard Way and Shaun Simon, including the android prostitutes Blue and Red, as well as the robot messiah DESTROYA.

1960s

• AM, from the short story I Have No Mouth, and I Must Scream by Harlan Ellison (1967)

1970s

• Proteus IV from Demon Seed by Dean Koontz (1973)
• Deep Thought, Marvin the Paranoid Android from The Hitchhiker's Guide to the Galaxy (1979)

1980s

• Wintermute and Neuromancer from Neuromancer by William Gibson
• Continuity, from Mona Lisa Overdrive by William Gibson

1990s

• The Librarian from the novel Snow Crash by Neal Stephenson
• Rei Toei from Idoru and All Tomorrow's Parties (novel) by William Gibson

2010s

• The Thunderhead, from the Arc of a Scythe series by Neal Shusterman, a post-singularity AI tasked with running the planet.^[1] It is a secondary character in the first novel and becomes a central character in the later novels.
• Skippy, the "absent-minded" AI from the Expeditionary Force (ExForce) series by Craig Alanson

1960s

• HAL 9000 from 2001: A Space Odyssey (1968)

1970s

• The Tabernacle from Zardoz (1974)

1980s

• Master Control Program, Sark and Tron from Tron (1982)
• WOPR from WarGames (1983)
• Skynet from the Terminator series
• SAL 9000 from 2010: The Year We Make Contact (1984)

1990s

• Agents Brown, Jones, and Smith from The Matrix. Other programs includes The Oracle (1999)
• S.E.T.H. (self evolving thought helix) from Universal Soldier: The Return (1999)

2000s

• The Oracle, Seraph, Merovingian, Persephone, and the Architect from The Matrix Reloaded. The Agent programs are upgraded. The new Agents included Jackson, Johnson, and Thompson. Agent Smith is now a computer virus with the ability to copy himself using humans and programs. (2003)
• The Oracle, Seraph, Sati, Rama Kandra, Kamala, Merovigian, Persephone, Architect, and Smith from The Matrix Revolutions. (2003)

2010s

• J.A.R.V.I.S. from the Iron Man, Iron Man 2, The Avengers, Iron Man 3, and Avengers: Age of Ultron.^[2]
• F.R.I.D.A.Y., replacement A.I. for Tony Stark / Iron Man, after J.A.R.V.I.S. became the Vision, from Avengers: Age of Ultron, Captain America: Civil War,^[3],^[4] Spider-Man: Homecoming, Avengers: Infinity War^[5] and Avengers: Endgame.
• Vision (formerly J.A.R.V.I.S.) from Avengers: Age of Ultron, Captain America: Civil War, and Avengers: Infinity War.
• Samantha from her (2013)
• STEM from Upgrade (2018)

2020s

• The Entity from Mission: Impossible – Dead Reckoning Part One (2023) and the untitled eighth film (2025).

1970s

• Orac and Zen from the BBC television series Blakes 7 (1978)

1980s

• Automan and Cursor from Automan (1983)
• Max Headroom, a TV host personality who appeared in various TV shows
• Data from Star Trek: The Next Generation (1987)
• Holly from the TV Sitcom Red Dwarf (1988)
• Ziggy from the sci-fi series Quantum Leap (1989)
• K.I.T.T. from Knight Rider

1990s

• MAL from Captain Planet and the Planeteers (1990)
• The Doctor hologram from Star Trek: Voyager (1995)

2000s

• The Andromeda Ascendant's avatars, including the android "Rommie", from Gene Roddenberry's Andromeda (2000)]
• D.A.V.E. (Digital Advanced Villain Emulator) from The Batman (2004)
• Mr Smith from The Sarah Jane Adventures (2007)
• Sigmund from Fanboy & Chum Chum (2009)

2010s

• The Machine from Person of Interest 2011-2016
• Poe from Altered Carbon 2018-2020

2020s

• Limòn from Brockmire 2020
• Mrs. Davis from Mrs. Davis 2023

1990s

• LINC and "Joey" from Beneath A Steel Sky
• SHODAN from the System Shock game series
• Deus from Xenogears
• Durandal, Leela, Tycho and other minor AI from Marathon (video game)

2000s

• Cortana from the Halo game series (also the inspiration for the name of Microsoft's real-world personal assistant in Windows 10)
• EDI from the Mass Effect game series
• GLaDOS from the Portal game series

• Daedelus, Icarus, Helios and other minor AI in Deus Ex.

2010s

• Commander Tartar from Splatoon 2: Octo Expansion
• Sage from Starlink: Battle for Atlas
• Turing, Baby Blue and Big Blue from 2064: Read Only Memories
• B.A.C.S. and J.A.C.S. from Void Bastards
• A.R.I.D from The Fall
• Five Pebbles, Looks To The Moon, No Significant Harassment, Seven Red Suns, Sliver Of Straw, Grey Wind and Unparalleled Innocence from Rain World