MRPS6

MRPS6

MRPS6

Protein-coding gene in the species Homo sapiens

28S ribosomal protein S6, mitochondrial is a protein that in humans is encoded by the MRPS6 gene.[5]

Quick Facts Available structures, PDB ...

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q.[5]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000243927 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000039680 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: MRPS6 mitochondrial ribosomal protein S6".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P82932 (28S ribosomal protein S6, mitochondrial) at the PDBe-KB.
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