MYO1G

MYO1G

MYO1G

Protein-coding gene in the species Homo sapiens

Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene.[5] MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain.[6] MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.

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Function

MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010].

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000136286 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000020437 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: Myosin IG". Retrieved 24 December 2019.
  6. [6]
    Olety B, Wälte M, Honnert U, Schillers H, Bähler M (February 2010). "Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity". FEBS Letters. 584 (3): 493–9. doi:10.1016/j.febslet.2009.11.096. PMID 19968988. S2CID 27557093.,

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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