S1PR4

S1PR4

S1PR4

Protein-coding gene in the species Homo sapiens

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.[5]

Quick Facts Available structures, PDB ...

Function

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.[5]

Evolution

Paralogues to S1PR4 Gene[6]

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000125910 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000044199 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: S1PR4 Sphingosine-1-phosphate receptor 4".
  6. [6]
    "Ensembl Genome Browser".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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