In the human brain, the superior cerebellar peduncle (brachium conjunctivum) is a paired structure of white matter that connects the cerebellum to the midbrain. It consists mainly of efferent fibers, the cerebellothalamic tract that runs from a cerebellar hemisphere to the contralateral thalamus, and the cerebellorubral tract that runs from a cerebellar hemisphere to the red nucleus. It also contains afferent tracts, most prominent of which is the ventral spinocerebellar tract. Other afferent tracts are the trigeminothalamic fibers, tectocerebellar fibers, and noradrenergic fibers from the locus coeruleus. The superior peduncle emerges from the upper and medial parts of the white matter of each hemisphere^{[citation needed]} and is placed under cover of the upper part of the cerebellum.

Superior cerebellar peduncles are connected together by the anterior medullary velum, which can be followed upward as far as the inferior colliculi, under which they disappear.

Below, they form the upper lateral boundaries of the fourth ventricle, but as they ascend they converge on the dorsal aspect of the ventricle and thus assist in forming its roof.

• Scheme showing the connections of the several parts of the brain.
• Superficial dissection of brain-stem. Lateral view.
• Axial section of the pons, at its dorsal (superior) part.
• Sagittal section through right cerebellar hemisphere. The right olive has also been cut sagittally.
• Dissection showing the course of the cerebrospinal fibers.
• Upper part of medulla spinalis and hind- and mid-brains; posterior aspect, exposed in situ.