RISC-loading complex subunit TARBP2 is a protein that in humans is encoded by the TARBP2 gene.^[5][6]

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TARBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CPN, 3ADL, 3LLH, 4WYQ
Identifiers
Aliases	TARBP2, LOQS, TRBP, TRBP1, TRBP2, RISC loading complex RNA binding subunit, TARBP2 subunit of RISC loading complex
External IDs	OMIM: 605053; MGI: 103027; HomoloGene: 7562; GeneCards: TARBP2; OMA:TARBP2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,500,921 bp[1] End 53,506,431 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 57.65 cM Start 102,426,627 bp[2] End 102,432,111 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right uterine tube right lobe of thyroid gland right adrenal gland right adrenal cortex mucosa of transverse colon granulocyte left lobe of thyroid gland right lobe of liver body of pancreas Top expressed in spermatocyte yolk sac testicle spermatid mesencephalon neural tube heart limb rhombencephalon muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding protein binding siRNA binding RNA binding enzyme binding pre-mRNA binding double-stranded RNA binding identical protein binding protein homodimerization activity pre-miRNA binding miRNA binding Cellular component cytoplasm cytosol perinuclear region of cytoplasm nucleus nucleoplasm nuclear body RISC-loading complex RISC complex Biological process regulation of viral transcription negative regulation of protein kinase activity multicellular organism growth positive regulation of translation single fertilization negative regulation of defense response to virus by host spermatid development positive regulation of viral genome replication regulation of translation production of miRNAs involved in gene silencing by miRNA miRNA metabolic process gene silencing production of siRNA involved in RNA interference pre-miRNA processing regulation of production of miRNAs involved in gene silencing by miRNA skeletal muscle tissue regeneration positive regulation of muscle cell differentiation neural precursor cell proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6895 21357 Ensembl ENSG00000139546 ENSMUSG00000023051 UniProt Q15633 P97473 RefSeq (mRNA) NM_004178 NM_134323 NM_134324 NM_001253795 NM_009319 RefSeq (protein) NP_004169 NP_599150 NP_599151 NP_001240724 NP_033345 Location (UCSC) Chr 12: 53.5 – 53.51 Mb Chr 15: 102.43 – 102.43 Mb PubMed search [3] [4]
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HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.^[6]

TARBP2 has been shown to interact with Protein kinase R^[7][8] and RBM14.^[9]