TEX14

TEX14

TEX14

Human protein encoded by TEX14 gene

Testis-expressed protein 14 is a protein in humans encoded by the TEX14 gene, and is 1497 amino acids in length.[5] TEX14 plays a vital role in the formation of germ cells, as it is an essential component of the mammalian germ cell interphase bridge.[6]

Quick Facts Available structures, PDB ...

An orthologue of TEX14 exists in other mammals, also called TEX14.

Function

During cell division, specifically in telophase, the spindle is converted into a midbody. This midbody contains a ring of TEX14, which gradually travels outwards as cell division progresses. Finally, TEX14 marks the ends of the intercellular bridge.[7]

Clinical significance

Male mice and male pigs that lack normal TEX14 are incapable of producing functional sperm, and thus are infertile.[6][8] However, TEX14-knockout female mice are not infertile.[9]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000121101 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000010342 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "TEX14 Gene - GeneCards | TEX14 Protein | TEX14 Antibody". www.genecards.org. Archived from the original on 2022-09-28. Retrieved 2022-09-28.
  6. [6]
    Greenbaum MP, Yan W, Wu MH, Lin YN, Agno JE, Sharma M, et al. (March 2006). "TEX14 is essential for intercellular bridges and fertility in male mice". Proceedings of the National Academy of Sciences of the United States of America. 103 (13): 4982–4987. Bibcode:2006PNAS..103.4982G. doi:10.1073/pnas.0505123103. PMC 1458781. PMID 16549803.
  7. [7]
    Greenbaum MP, Ma L, Matzuk MM (May 2007). "Conversion of midbodies into germ cell intercellular bridges". Developmental Biology. 305 (2): 389–396. doi:10.1016/j.ydbio.2007.02.025. PMC 2717030. PMID 17383626.
  8. [8]
    Sironen A, Uimari P, Venhoranta H, Andersson M, Vilkki J (December 2011). "An exonic insertion within Tex14 gene causes spermatogenic arrest in pigs". BMC Genomics. 12 (1): 591. doi:10.1186/1471-2164-12-591. PMC 3248578. PMID 22136159.
  9. [9]
    Greenbaum MP, Iwamori N, Agno JE, Matzuk MM (March 2009). "Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility". Biology of Reproduction. 80 (3): 449–457. doi:10.1095/biolreprod.108.070649. PMC 2805395. PMID 19020301.
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