WNT9A

WNT9A

WNT9A

Protein-coding gene in the species Homo sapiens

Protein Wnt-9a (formerly Wnt14[5]) is a protein that in humans is encoded by the WNT9A gene.[6][7]

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The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.[7]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000143816 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000000126 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Person AD, Garriock RJ, Krieg PA, Runyan RB, Klewer SE (2005). "Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development". Developmental Biology. 278 (1): 35–48. doi:10.1016/j.ydbio.2004.10.013. PMID 15649459.
  6. [6]
    Bergstein I, Eisenberg LM, Bhalerao J, Jenkins NA, Copeland NG, Osborne MP, Bowcock AM, Brown AM (Mar 1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics. 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749.
  7. [7]
    "Entrez Gene: WNT9A wingless-type MMTV integration site family, member 9A".

Further reading



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