(KDO)2-lipid_IVA_(2-8)_3-deoxy-D-manno-octulosonic_acid_transferase

(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase

(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase

Class of enzymes

(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.14, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)2-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->8) glycosidic bond-forming).[1][2][3] This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP
Quick Facts Identifiers, EC no. ...

The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes.

References

  1. [1]
    Löbau S, Mamat U, Brabetz W, Brade H (November 1995). "Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183". Molecular Microbiology. 18 (3): 391–9. doi:10.1111/j.1365-2958.1995.mmi_18030391.x. PMID 8748024.
  2. [2]
    Mamat U, Baumann M, Schmidt G, Brade H (December 1993). "The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology". Molecular Microbiology. 10 (5): 935–41. doi:10.1111/j.1365-2958.1993.tb00965.x. PMID 7523826.
  3. [3]
    Belunis CJ, Mdluli KE, Raetz CR, Nano FE (September 1992). "A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope". The Journal of Biological Chemistry. 267 (26): 18702–7. PMID 1382060.
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