(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline_N-methyltransferase

(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

Class of enzymes

In enzymology, a (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase is an enzyme that catalyzes the chemical reaction:[1]

S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
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This enzyme participates in alkaloid biosynthesis.

Nomenclature

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase. This enzyme is also called norreticuline N-methyltransferase.

References

  1. [1]
    Frenzel T, Zenk MH (1990). "Purification and characterization of three isoforms of S-adenosyl-L-methionine: (R,S)-tetrahydrobenzyl-isoquinoline N-methyltransferase from Berberis koetineana cell cultures". Phytochemistry. 29 (11): 3491–3497. doi:10.1016/0031-9422(90)85263-F.


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