16S_rRNA_(guanine1207-N2)-methyltransferase

16S rRNA (guanine1207-N2)-methyltransferase

16S rRNA (guanine1207-N2)-methyltransferase

Class of enzymes

16S rRNA (guanine1207-N2)-methyltransferase (EC 2.1.1.172, m2G1207 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine1207-N2)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine1207 in 16S rRNA S-adenosyl-L-homocysteine + N2-methylguanine1207 in 16S rRNA
Quick Facts 1207-N2)-methyltransferase, Identifiers ...

The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA.

References

  1. [1]
    Tscherne JS, Nurse K, Popienick P, Ofengand J (January 1999). "Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli". The Journal of Biological Chemistry. 274 (2): 924–9. doi:10.1074/jbc.274.2.924. PMID 9873033.
  2. [2]
    Sunita S, Purta E, Durawa M, Tkaczuk KL, Swaathi J, Bujnicki JM, Sivaraman J (2007). "Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC". Nucleic Acids Research. 35 (13): 4264–74. doi:10.1093/nar/gkm411. PMC 1934991. PMID 17576679.
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