The 1910 Ilkeston by-election was a Parliamentary by-election in the constituency of Ilkeston in Derbyshire. It returned one Member of Parliament (MP) to the House of Commons of the United Kingdom, elected by the first past the post voting system. The by-election was held on 7 March 1910.

The by-election was held due to the incumbent Liberal MP, Walter Foster, becoming Baron Ilkeston and taking a seat in the House of Lords. Foster had been Liberal MP for the seat of Ilkeston since the 1887 Ilkeston by-election.

The seat had been Liberal since it was created in 1885. They easily held the seat at the last election, with a reduced majority;

• The local Liberal Association selected 42-year-old Rt Hon. Jack Seely to defend the seat.

Polling Day was fixed for the 7 March 1910.

The Liberals held the seat and managed a slightly reduced majority;