The following is the 1950–51 network television schedule for the four major English language commercial broadcast networks in the United States. The schedule covers primetime hours from September 1950 through March 1951. The schedule is followed by a list per network of returning series, new series, and series cancelled after the 1949–50 season. This season became the first in which primetime was entirely covered by the networks. It was also the inaugural season of the Nielsen rating system. Late in the season, the coast-to-coast link was in service.

In September 1950 NBC added two live variety series, Four Star Revue and The Colgate Comedy Hour, to its fall schedule. These programs were a network effort to bring NBC's most popular radio stars to television; talent included Eddie Cantor, Jack Carson, Dean Martin and Jerry Lewis, Jimmy Durante, Danny Thomas, Ed Wynn, Bob Hope and Fred Allen. The two new star-studded series were scheduled directly against two of CBS's most popular programs: Four Star Revue went up against Arthur Godfrey and Friends on Wednesday nights, while The Colgate Comedy Hour was slated against Toast of the Town. NBC was confident that its strategy would pay off.^[1]

CBS answered NBC's schedule with big radio stars and variety programs of its own, bringing in Frank Sinatra and (in occasional specials) Bing Crosby, Jack Benny, and Edgar Bergen. "Despite the big budget variety shows in its schedule, though, CBS felt that situation comedy was actually a more stable television form that would be easier to exploit in the long run."^[1]

In many time slots, the underfunded DuMont Network did not bother to compete against NBC's or CBS's hit series, instead airing what some TV historians have called "time-filler". For example: "During its long run [The Johns Hopkins Science Review] was scheduled against such hit shows as Break the Bank [and] Dragnet, programs from which its network had little chance of luring away viewers."^[2] During fall 1950, The Court of Current Issues and The Johns Hopkins Science Review'' aired at the same time as the most heavily viewed program on television, NBC's Texaco Star Theater. Given the competition, DuMont's Tuesday night public-affairs programming attracted virtually no audience. The network had some success with a crime drama that had debuted in January the previous season titled Inside Detective (later retitled Rocky King Detective), which became one of the longest-running series on the network. Another DuMont series to debut during the season, Star Time, while short-lived, is remembered for including a television version of the popular radio sketches The Bickersons, and for being an early example of a sponsored network series to feature an African-American as a regular (jazz pianist Teddy Wilson, a familiar member of the Benny Goodman Sextet).

New fall series are highlighted in bold.

Note: On CBS, beginning in January, The Jack Benny Program aired as occasional specials once every six to eight weeks.

Hopalong Cassidy (9/39.9) aired on NBC from 6:00 to 7:00 p.m. The Bigelow Theatre aired on CBS from 6:00 to 6:30 p.m. from December 1950 to June 1951.

• Wayne King was seen only on NBC's Midwest Network.

Notes: On CBS, Big Top aired from 6:30 to 7:30 p.m. Eastern Time from September 1950 to January 6, 1951, after which it moved to Saturdays from noon to 1:00 p.m., where it ran for another seven years. Faye Emerson's Wonderful Town began on June 16, 1951, and concluded its 42-episode run at 9 p.m. on April 12, 1952.