The 1968 Colorado Buffaloes football team represented the University of Colorado in the Big Eight Conference during the 1968 NCAA University Division football season. Led by sixth-year head coach Eddie Crowder, Colorado finished the regular season at 4–6 (3–4 in Big 8, fourth), and played their home games on campus at Folsom Field in Boulder, Colorado.

Colorado featured 18 sophomores on the two-deep depth chart and endured an up-and-down season, including the second straight win over Oklahoma in Boulder to improve to 4–2,^[1] but then lost four straight in November to conclude the season. The finale was the first loss to Air Force in five years; the Falcons finished at 7–3.^[2]

This was the Buffs' first losing season in four years; their next came five years later.

More information Date, Opponent ...

Date	Opponent	Site	TV	Result	Attendance
September 21	Oregon*	Folsom Field Boulder, CO		W 28–7	44,723
September 28	at California*	California Memorial Stadium Berkeley, CA	ABC	L 0–10	27,500
October 5	at Iowa State	Clyde Williams Field Ames, IA		W 28–18	24,500
October 12	at Missouri	Memorial Stadium Columbia, MO		L 14–27	50,705
October 19	Kansas State	Folsom Field Boulder, CO (rivalry)		W 37–14	32,500
October 26	Oklahoma	Folsom Field Boulder, CO		W 41–27	47,724
November 2	at No. 3 Kansas	Memorial Stadium Lawrence, KS		L 14–27	43,442–44,500
November 9	at Oklahoma State	Lewis Field Stillwater, OK		L 17–34	17,500
November 16	Nebraska	Folsom Field Boulder, CO (rivalry)		L 6–22	48,327
November 23	Air Force*	Folsom Field Boulder, CO		L 35–58	42,300
*Non-conference game Homecoming Rankings from AP Poll released prior to the game

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