2-Aminopurine

2-Aminopurine

2-Aminopurine

Chemical compound

2-Aminopurine, a purine analog of guanine and adenine, is a fluorescent molecular marker used in nucleic acid research.[1] It most commonly pairs with thymine as an adenine-analogue, but can also pair with cytosine as a guanine-analogue.[2] For this reason it is sometimes used in the laboratory for mutagenesis.

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References

  1. [1]
    Jean JM, Hall KB (2001). "2-Aminopurine fluorescence quenching and lifetimes: role of base stacking". Proc. Natl. Acad. Sci. U.S.A. 98 (1): 37–41. doi:10.1073/pnas.011442198. PMC 14540. PMID 11120885.
  2. [2]
    Sowers LC, Fazakerley GV, Eritja R, Kaplan BE, Goodman MF (1986). "Base pairing and mutagenesis: observation of a protonated base pair between 2-aminopurine and cytosine in an oligonucleotide by proton NMR". Proc. Natl. Acad. Sci. U.S.A. 83 (15): 5434–5438. Bibcode:1986PNAS...83.5434S. doi:10.1073/pnas.83.15.5434. PMC 386301. PMID 3461441.
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