2-Deoxy-scyllo-inosamine_dehydrogenase_(SAM-dependent)

2-Deoxy-scyllo-inosamine dehydrogenase (SAM-dependent)

2-Deoxy-scyllo-inosamine dehydrogenase (SAM-dependent)

Enzyme

2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) (EC 1.1.99.38, btrN (gene)) is an enzyme with systematic name 2-deoxy-scyllo-inosamine:S-adenosyl-L-methionine 1-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine
Quick Facts Identifiers, EC no. ...

This enzyme participates in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family.

References

  1. [1]
    Yokoyama K, Numakura M, Kudo F, Ohmori D, Eguchi T (December 2007). "Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin". Journal of the American Chemical Society. 129 (49): 15147–55. doi:10.1021/ja072481t. PMID 18001019.
  2. [2]
    Yokoyama K, Ohmori D, Kudo F, Eguchi T (August 2008). "Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy". Biochemistry. 47 (34): 8950–60. doi:10.1021/bi800509x. PMID 18672902.
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