The 2001 Major League Baseball All-Star Game was the 72nd playing of the midsummer classic between the all-stars of the American League (AL) and National League (NL), the two leagues comprising Major League Baseball. The game was held on July 10, 2001 at Safeco Field in Seattle, Washington, home of the Seattle Mariners of the American League. The American League defeated the National League, 4–1. This was Cal Ripken Jr.'s 19th and final All-Star Game. It was also the final All-Star Game for San Diego Padres right fielder Tony Gwynn.

The American League squad for the game featured eight players from the Seattle Mariners.^[1]

• Cal Ripken Jr., most famous during his career as a shortstop, was elected as a third baseman to start the game. Texas Rangers shortstop Alex Rodriguez was elected to start at short. However, Rodriguez insisted that Ripken play shortstop for the first inning. American League manager Joe Torre agreed and allowed the change. When fans noticed the fielding change, they gave both players a standing ovation.^[3]
• This was the first All-Star Game to be awarded by Commissioner Bud Selig after being named to that post.
• American League starting pitcher Roger Clemens was booed in the pregame ceremonies for striking out 15 Mariners in a one-hit shutout in the previous season's playoffs. Also in the pregame ceremony, the Fort Lewis color guard provided the colors presentation, accompanied by Tacoma and Everett, Washington high school students who presented the flags in the outfield. After Diana Krall and Mýa sang the Canadian and U.S. national anthems, respectively, Tony Pérez, as the only link to the 1979 All-Star Game, the only other All-Star Game in Seattle, joined the ceremonial first pitch ceremonies.
• The film Summer Catch had a premiere in Seattle at the now-defunct theater chain General Cinemas Pacific Place 12 to coincide with the All-Star Game. In attendance was Meatloaf, Jessica Biel, Wilmer Valderrama and fellow That '70s Show costar Danny Masterson.^{[citation needed]}