The 2010 Subway Jalapeño 250 powered by Coca-Cola was a NASCAR Nationwide Series race held on July 2, 2010, at Daytona International Speedway in Daytona Beach, Florida. The race was the 17th race of the 2010 NASCAR Nationwide Series. It was the 9th running of the event. The race was also the first for the new Nationwide COT (Car of Tomorrow) Cars at a Superspeedway. Brad Keselowski won the pole but it was Dale Earnhardt Jr. who led the most laps and took home an emotional victory as he drove the #3 Wrangler Jeans Chevrolet throwback scheme to victory lane and was the first Earnhardt to drive the #3 to victory lane since his father in 2000. Jr. later would say he would never run the #3 in his career ever again.^[2]

Daytona International Speedway is a race track in Daytona Beach, Florida, United States. Since opening in 1959, it has been the home of the Daytona 500, the most prestigious race in NASCAR as well as its season opening event. In addition to NASCAR, the track also hosts races for ARCA, AMA Superbike, IMSA, SCCA, and Motocross. The track features multiple layouts including the primary 2.500 mi (4.023 km) high-speed tri-oval, a 3.560 mi (5.729 km) sports car course, a 2.950 mi (4.748 km) motorcycle course, and a 1,320 ft (402.3 m) karting and motorcycle flat-track. The track's 180-acre (72.8 ha) infield includes the 29-acre (11.7 ha) Lake Lloyd, which has hosted powerboat racing. The speedway is operated by NASCAR pursuant to a lease with the City of Daytona Beach on the property that runs until 2054.^[3] Dale Earnhardt is Daytona International Speedway's all-time winningest driver, with a total of 34 career victories (12- Daytona 500 Qualifying Races) (7- NASCAR Xfinity Series Races) (6- Busch Clash Races) (6- IROC Races) (2- Pepsi 400 July Races) (1- The 1998 Daytona 500).

Brad Keselowski won the pole with a time of 49.172 and a speed of 183.031. Penske Racing dominated the first two rows with Keselowski's teammates Parker Kligerman and Justin Allgaier starting in 2nd and 4th.^[4]

* – Made the field via owners points.

** – Jennifer Jo Cobb, Reed Sorenson, Kevin Lepage, and Trevor Bayne all had to start at the rear of the field. Sorenson and Lepage had adjustments during impound, Cobb had a transmission change, and Bayne missed the drivers meeting.

Pole sitter Brad Keselowski led the first lap of the race. On lap 3, Dale Earnhardt Jr. took the lead from Keselowski while the moment of silence was going on to honor Dale Earnhardt but Keselowski immeadeatly took it back off of turn 4. On lap 6, Earnhardt Jr. tried again but failed to do so. The first caution flew on lap 7 when Jennifer Jo Cobb and Johnny Chapman crashed in turn 4. The race would restart on lap 12. On the restart, Kevin Harvick took the lead from Keselowski. On lap 14, Carl Edwards took the lead with a push from Clint Bowyer. On lap 16, Clint Bowyer took the lead. On lap 27, Keselowski took the lead from Bowyer. On lap 32, Brad Keselowski went to pit giving the lead to Kyle Busch. While that was happening, the second caution flew when Michael Annett spun after he got loose coming out of turn 4. Kyle Busch won the race off of pit road and led the field to the restart on lap 36. On lap 41, Joey Logano took the lead but Clint Bowyer would take it on the next lap. On lap 48, Kyle Busch took the lead. On lap 50, Justin Allgaier took the lead.