The 2011 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2011 NCAA Division I FCS football season. Led by second-year head coach Karl Morgan, the Delta Devils compiled an overall record of 1–10 and a mark of 1–8 in conference play, tying for fourth place in the SWAC's East Division. Mississippi Valley State played home games at Rice–Totten Stadium in Itta Bena, Mississippi.

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Date	Time	Opponent	Site	Result	Attendance
September 3	5:00 pm	Alabama State	Rice–Totten Stadium Itta Bena, MS	L 9–41	3,780
September 10	4:00 pm	Murray State*	Rice–Totten Stadium Itta Bena, MS	L 0–39	2,209
September 17	4:00 pm	at Alcorn State	Casem-Spinks Stadium Lorman, MS	L 14–39	13,500
September 24	7:00 pm	at Prairie View A&M	Edward L. Blackshear Field Prairie View, TX	L 34–43	5,149
October 1	2:00 pm	Southern	Rice–Totten Stadium Itta Bena, MS	L 21–28	4,982
October 8	1:00 pm	at Alabama A&M	Louis Crews Stadium Huntsville, AL	L 14–37	16,827
October 15	2:00 pm	No. 25 Jackson State	Rice–Totten Stadium Itta Bena, MS	L 16–17	9,420
October 22	2:00 pm	at Grambling State	Eddie Robinson Stadium Grambling, LA	L 24–30	11,137
October 29	2:00 pm	Texas Southern	Rice–Totten Stadium Itta Bena, MS	W 12–9	7,839
November 3	6:30 pm	at South Alabama*	Ladd–Peebles Stadium Mobile, AL	L 3–35	13,807
November 12	1:00 pm	Arkansas–Pine Bluff	Rice–Totten Stadium Itta Bena, MS	L 3–15	4,209
*Non-conference game Homecoming Rankings from The Sports Network Poll released prior to the game All times are in Central time

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