The 2012 East–West Shrine Game was the 87th staging of the all-star college football exhibition game featuring NCAA Division I Football Bowl Subdivision players and a few select invitees from Canadian university football. The game featured over 100 players from the 2011 college football season, and prospects for the 2012 Draft of the professional National Football League (NFL). In the week prior to the game, scouts from all 32 NFL teams attended. The proceeds from the East-West Shrine Game benefit Shriners Hospitals for Children. Brad Childress and Bobby Ross were named coaches on December 19, 2011.

This oldest all-star game was played on January 21, 2012, at 4 p.m. ET at the Tropicana Field. The radio broadcast team was Patrick Kinas and Brian Jordan in the radio booth, and Rick Berkey reporting from the sidelines. The Pat Tillman Award was presented to Tauren Poole (RB, Tennessee) as a player who "best exemplifies character, intelligence, sportsmanship and service".^[3]

• This was the third time the game was played in Florida; having been played the prior two years at the Florida Citrus Bowl in Orlando, this was the first time it was held in St. Petersburg.^[4]