| 2021 Purdue Fort Wayne Mastodons baseball game log |
| Regular season |
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| # | Date | Opponent | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | Horizon record |
| 1 | February 26 | at Murray State | Reagan Field • Murray, Kentucky | 10–6 | Miller (1–0) | Gardner (0–1) | None | 100 | 1–0 | – |
| 2 | February 26 | at Murray State | Reagan Field • Murray, Kentucky | 5–9 | Wenninger (1–0) | Boyd (0–1) | None | 50 | 1–1 | – |
| 3 | February 27 | at Murray State | Reagan Field • Murray, Kentucky | 4–5 | Pennington (1–0) | Fee (0–1) | – | 107 | 1–2 | – |
| 4 | February 27 | at Murray State | Reagan Field • Murray, Kentucky | 2–3 | Whaley (1–0) | Madura (0–1) | Holden (1) | 86 | 1–3 | – |
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| # | Date | Opponent | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | Horizon record |
| 5 | March 5 | vs Youngstown State | Defiance High School • Defiance, Ohio | 3–6 | Clark (1–2) | Miller (1–1) | Clift Jr. (3) | 0 | 1–4 | 0–1 |
| 6 | March 6 | vs Youngstown State | Defiance High School • Defiance, Ohio | 0–3 | Floyd (1–1) | Boyd (0–2) | None | 0 | 1–5 | 0–2 |
| 7 | March 6 | vs Youngstown State | Defiance High School • Defiance, Ohio | 1–0 | Myers (1–0) | Cole (0–1) | None | 0 | 2–5 | 1–2 |
| 8 | March 7 | vsYoungstown State | Defiance High School • Defiance, Ohio | 8–13 | Perez (1–0) | Madura (0–2) | None | 0 | 2–6 | 1–3 |
| 9 | March 12 | at Butler | Bulldog Park • Indianapolis, Indiana | 6–3 | Miller (2–1) | Schultz (0–1) | Robison (2) | 150 | 3–6 | 1–3 |
| 10 | March 13 | at Butler | Bulldog Park • Indianapolis, Indiana | 0–2 | Myers (1–0) | Boyd (0–3) | Pilcher (1) | 150 | 3–7 | 1–3 |
| 11 | March 14 | at Butler | Bulldog Park • Indianapolis, Indiana | 9–6 | Myer (2–0) | Vore (1–0) | Robison (3) | 150 | 4–7 | 1–3 |
| 12 | March 19 | Oakland | Mastodon Field • Fort Wayne, Indiana | 3–9 | Deans (3–0) | Miller (2–2) | None | 89 | 4–8 | 1–4 |
| 13 | March 20 | Oakland | Mastodon Field • Fort Wayne, Indiana | 5–4 | Robison (1–0) | Hill (1–1) | None | 112 | 5–8 | 2–4 |
| 14 | March 20 | Oakland | Mastodon Field • Fort Wayne, Indiana | 6–3 | Myer (3–0) | Hill (1–2) | Robison (4) | 121 | 6–8 | 3–4 |
| 15 | March 21 | Oakland | Mastodon Field • Fort Wayne, Indiana | 8–7 | Miller (3–2) | Tucker (0–3) | None | 125 | 7–8 | 4–4 |
| 16 | March 26 | at Milwaukee | Routine Field • Franklin, Wisconsin | 3–6 | Neu (2–0) | Robison (1–1) | Blubaugh (1) | 395 | 7–9 | 4–5 |
| 17 | March 27 | at Milwaukee | Routine Field • Franklin, Wisconsin | 6–5 | Wohlt (1–0) | Myer (3–1) | None | 451 | 7–10 | 4–6 |
| 18 | March 27 | at Milwaukee | Routine Field • Franklin, Wisconsin | 2–5 | LaRock (1–1) | Boyd (0–4) | McCarthy (2) | 451 | 7–11 | 4–7 |
| 19 | March 28 | at Milwaukee | Routine Field • Franklin, Wisconsin | 3–14 | Mahoney (2–3) | Pintarich (0–1) | None | 343 | 7–12 | 4–8 |
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| # | Date | Opponent | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | Horizon record |
| 20 | April 1 | Northern Kentucky | World Baseball Academy • Fort Wayne, Indiana | 14–0 | Pintarich (1–1) | Gerl (1–2) | None | 87 | 8–12 | 5–8 |
| 21 | April 2 | Northern Kentucky | Parkview Field • Fort Wayne, Indiana | 4–5 | Richardson (2–0) | Myer (3–2) | Noble (1) | 121 | 8–13 | 5–9 |
| 22 | April 2 | Northern Kentucky | Parkview Field • Fort Wayne, Indiana | 10–11 | Klingenbeck (3–2) | Miller (3–3) | Ollier (3) | – | 8–14 | 5–10 |
| 23 | April 3 | Northern Kentucky | Parkview Field • Fort Wayne, Indiana | 9–8 | Evenson (1–0) | Ollier (0–2) | None | – | 9–14 | 6–10 |
| 24 | April 9 | at Wright State | Nischwitz Stadium • Dayton, Ohio | Canceled (COVID-19) |
| 25 | April 10 | at Wright State | Nischwitz Stadium • Dayton, Ohio | Canceled (COVID-19) |
| 26 | April 10 | at Wright State | Nischwitz Stadium • Dayton, Ohio | Canceled (COVID-19) |
| 27 | April 11 | at Wright State | Nischwitz Stadium • Dayton, Ohio | Canceled (COVID-19) |
| 28 | April 16 | at UIC | Les Miller Field at Curtis Granderson Stadium • Chicago, Illinois | 0–1 | Key (4–2) | Pintarich (1–2) | None | 35 | 9–15 | 6–11 |
| 29 | April 17 | at UIC | Les Miller Field at Curtis Granderson Stadium • Chicago, Illinois | 0–2 | O'Reilly (2–5) | Myers (3–3) | Morris (1) | 76 | 9–16 | 6–12 |
| 30 | April 17 | at UIC | Les Miller Field at Curtis Granderson Stadium • Chicago, Illinois | 2–4 | Torres (3–1) | Miller (3–4) | Gosbeth (2) | 81 | 9–17 | 6–13 |
| 31 | April 18 | at UIC | Les Miller Field at Curtis Granderson Stadium • Chicago, Illinois | 4–11 | Nicholson (1–0) | Fee (0–2) | None | 70 | 9–18 | 6–14 |
| 32 | April 23 | at Ohio | Bob Wren Stadium • Athens, Ohio | 2–12 | Rock (7–1) | Pintarich (1–3) | None | – | 9–19 | 6–14 |
| 33 | April 24 | at Ohio | Bob Wren Stadium • Athens, Ohio | 2–5 | Kutt IV (5–2) | Myer (3–4) | None | – | 9–20 | 6–14 |
| 34 | April 25 | at Ohio | Bob Wren Stadium • Athens, Ohio | 1–9 | Jones (2–2) | Miller (3–5) | None | – | 9–21 | 6–14 |
| 35 | April 30 | Wright State | Mastodon Field • Fort Wayne, Indiana | 1–9 | Schrand (4–4) | Pintarich (1–4) | None | 81 | 9–22 | 6–15 |
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| # | Date | Opponent | Site/stadium | Score | Win | Loss | Save | Attendance | Overall record | Horizon record |
| 36 | May 1 | Wright State | Mastodon Field • Fort Wayne, Indiana | 2–22 | Brehmer (6–2) | Myer (3–5) | None | 98 | 9–23 | 6–16 |
| 37 | May 1 | Wright State | World Baseball Academy • Fort Wayne, Indiana | 7–28 | Shirk (3–0) | Miller (3–6) | None | 111 | 9–24 | 6–17 |
| 38 | May 2 | Wright State | World Baseball Academy • Fort Wayne, Indiana | 6–29 | Cline (6–1) | Boyd (0–5) | None | 147 | 9–25 | 6–18 |
| 39 | May 7 | at Youngstown State | Eastwood Field • Niles, Ohio | 2–6 | Floyd (7–3) | Fee (0–3) | None | 219 | 9–26 | 6–19 |
| 40 | May 7 | at Youngstown State | Eastwood Field • Niles, Ohio | 4–15 | Clark (5–5) | Pintarich (1–5) | None | 219 | 9–27 | 6–20 |
| 41 | May 8 | at Youngstown State | Eastwood Field • Niles, Ohio | 3–1 | Miller (4–6) | Clift Jr. (2–3) | Boyd (1) | 218 | 10–27 | 7–20 |
| 42 | May 8 | at Youngstown State | Eastwood Field • Niles, Ohio | 5–7 | Coles (2–2) | Boyd (0–6) | None | 218 | 10–28 | 7–21 |
| 43 | May 14 | UIC | Mastodon Field • Fort Wayne, Indiana | 7–22 | Key (6–3) | Pintarich (1–6) | None | 101 | 10–29 | 7–22 |
| 44 | May 15 | UIC | Mastodon Field • Fort Wayne, Indiana | 2–20 | Torres (6–1) | Myer (3–6) | None | 168 | 10–30 | 7–23 |
| 45 | May 15 | UIC | Mastodon Field • Fort Wayne, Indiana | 6–18 | O'Reilly (4–5) | Miller (4–7) | None | 177 | 10–31 | 7–24 |
| 46 | May 16 | UIC | Mastodon Field • Fort Wayne, Indiana | 0–10 | Conrad (1–0) | Boyd (0–7) | None | 143 | 10–32 | 7–25 |
| 47 | May 21 | at Oakland | Oakland Baseball Field • Rochester, Michigan | 12–4 | 'Miller (5–7) | Konitzer (3–2) | None | 33 | 11–32 | 8–25 |
| 48 | May 21 | at Oakland | Oakland Baseball Field • Rochester, Michigan | 13–17 | Densmore (3–4) | Armstrong (0–1) | Paugh (1) | 33 | 11–33 | 8–26 |
| 49 | May 22 | at Oakland | Oakland Baseball Field • Rochester, Michigan | 5–6 | Nierman (4–6) | Myer (3–7) | None | 88 | 11–34 | 8–27 |
| 50 | May 22 | at Oakland | Oakland Baseball Field • Rochester, Michigan | 10–17 | Trovinger (1–0) | Fee (0–4) | None | 88 | 11–35 | 8–28 |
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