The 2021 YellaWood 500 was a NASCAR Cup Series race held on October 4, 2021, at Talladega Superspeedway in Lincoln, Alabama. Originally scheduled for 188 laps on the 2.66 mi (4.28 km) asphalt superspeedway, the race was shortened to 117 laps by rain.^[5] It was the 31st race of the 2021 NASCAR Cup Series season, the fifth race of the Playoffs, and the second race of the Round of 12. The race was postponed from Sunday, October 3 to Monday, October 4, due to rain. Bubba Wallace took his first victory in the NASCAR Cup Series. It was the first time since the development of the 2014 NASCAR Playoffs format that a driver not in either level of playoffs had won a race, and the first non-playoff driver to win a race since the 2013 Talladega playoff race, as well the first win for an African-American driver in the Cup Series since Wendell Scott's win in 1963.

It was the shortest Cup Series race at Talladega Superspeedway, and only the fourth Cup Series race to be shortened at Talladega (the May 1974 race was shortened to 170 laps due to the Energy Crisis, the May 1987 race was shortened to 178 laps by darkness after catch fencing had to be repaired, and the July 1996 race was shortened to 129 laps because of a long rain delay and subsequent darkness). It was the third of five national series races to be shortened in 2021 at Talladega.

Denny Hamlin was awarded the pole for the race as determined by competition-based formula. ^[4]

Denny Hamlin was the pole sitter for the race. The race was forced to be delayed until the following day due to rain. The next day, NASCAR would be able to get the race started at 1PMET, 12 PM local time. Chris Buescher won Stage 1 for his 2nd stage win of the season and the first since February at Homestead-Miami Speedway. At the end of Stage 2, rain hit the area. And the race was past its halfway point (Lap 94), so whoever was leading could possibly win the race. Bubba Wallace was leading when the rain hit. After a long red flag, NASCAR declared the race official and Wallace won his first career Cup Series race along with Stage 2 of the race. It was also the first win for 23XI Racing, the new team co-owned by Denny Hamlin and Michael Jordan which debuted this season.