The 2021–22 Honduran Liga Nacional season was the 56th Honduran Liga Nacional edition since its establishment in 1965. The tournament started in September 2021 and is scheduled to end in mid 2022. The season is divided into two halves (Apertura and Clausura), each crowning one champion. Due to the impact of the COVID-19 pandemic on association football, a new and more compact format is to be used.^[1] The first stage was shortened from 18 to 14 weeks. The tournament is divided into two groups of five. The top teams of each group advance directly to the semifinal round, and the teams finishing 2nd and 3rd from each group have to play a playoff round. At the end of the season, the three teams with the best record qualify to the 2022 CONCACAF League.

A total of 10 teams will contest the tournament, the same that participated in the 2019–20 season since no relegation was implemented.

This is a list of foreign players in the 2021–22 season. The following players:

1. Have played at least one game for the respective club.
2. Have not been capped for the Honduras national football team on any level, independently from the birthplace

(player released during the Apertura season) (player released between the Apertura and Clausura seasons) (player released during the Clausura season) (player naturalised for the Clausura season)

• LNP Official