The 2022 Prospect League season was the 13th season of collegiate summer baseball in the Prospect League, a collegiate summer baseball league in the Midwestern United States, since its creation in June 2009. There are 16 Prospect League teams, split evenly between Eastern and Western Conferences. These conferences are then split up between the Ohio River Valley, Wabash River, Great River, and Prairie Land divisions.

The Cape Catfish entered the season as defending champions, having defeated the Lafayette Aviators, two games to one, in the league's 2021 championship series.^[1]

Very little changed for the 2022 season, with the only difference in the team lineup being an ownership and name change for the Springfield, Ill. franchise as the Sliders became the Lucky Horseshoes. A new franchise for Jackson, Tennessee, was announced, which will take the field beginning with the 2023 season at the former home of the class Double-A Jackson Generals, The Ballpark at Jackson.^[2]

The 16 teams in the league are split evenly between two conferences Eastern and Western. These two conferences are then split up into four divisions, Ohio River Valley, Wabash River, Great River, and Prairie Land.

The season will be played with a 60-game schedule, which is split between two halves, with the first-half ending on July 4 and second-half ending on August 6. The first-half winners in each division will host the second-half winners in a one-game divisional championship round. (If the same team wins both halves, the team with the next-best second-half record makes the playoffs).^[3]

• 2022 NCAA Division I baseball season
• 2022 NCAA Division I baseball tournament
• 2022 College World Series
• 2022 NCAA Division III baseball tournament