23S_rRNA_(guanine745-N1)-methyltransferase

23S rRNA (guanine745-N1)-methyltransferase

23S rRNA (guanine745-N1)-methyltransferase

Class of enzymes

23S rRNA (guanine745-N1)-methyltransferase (EC 2.1.1.187, Rlma(I), Rlma1, 23S rRNA m1G745 methyltransferase, YebH, RlmAI methyltransferase, ribosomal RNA(m1G)-methylase, rRNA(m1G)methylase, RrmA, 23S rRNA:m1G745 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine745-N1)-methyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine745 in 23S rRNA S-adenosyl-L-homocysteine + N1-methylguanine745 in 23S rRNA
Quick Facts 745-N1)-methyltransferase, Identifiers ...

The enzyme specifically methylates guanine745 at N1 in 23S rRNA.

References

  1. [1]
    Liu M, Novotny GW, Douthwaite S (November 2004). "Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase". RNA. 10 (11): 1713–20. doi:10.1261/rna.7820104. PMC 1370659. PMID 15388872.
  2. [2]
    Gustafsson C, Persson BC (January 1998). "Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant". Journal of Bacteriology. 180 (2): 359–65. doi:10.1128/JB.180.2.359-365.1998. PMC 106891. PMID 9440525.
  3. [3]
    Das K, Acton T, Chiang Y, Shih L, Arnold E, Montelione GT (March 2004). "Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site". Proceedings of the National Academy of Sciences of the United States of America. 101 (12): 4041–6. Bibcode:2004PNAS..101.4041D. doi:10.1073/pnas.0400189101. PMC 384692. PMID 14999102.
  4. [4]
    Hansen LH, Kirpekar F, Douthwaite S (July 2001). "Recognition of nucleotide G745 in 23 S ribosomal RNA by the rrmA methyltransferase". Journal of Molecular Biology. 310 (5): 1001–10. doi:10.1006/jmbi.2001.4836. PMID 11501991.
  5. [5]
    Liu M, Douthwaite S (April 2002). "Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria". Molecular Microbiology. 44 (1): 195–204. doi:10.1046/j.1365-2958.2002.02866.x. PMID 11967079.
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