An ACE inhibitor and thiazide combination is a drug combination used to treat hypertension (high blood pressure). They are given by mouth. ACE inhibitors reduce the activity of angiotensin-converting enzyme (ACE) which produces angiotensin II, a hormone that constricts blood vessels. Thiazides are a class of diuretics that inhibit the thiazide receptor, thereby increasing urine production and reducing excess water and salt in the body. Several organizations recommend combination therapy for hypertension in cases of failure of a single drug to achieve target blood pressure, or even as a first line treatment for some patients.^[1]

• Enalapril/hydrochlorothiazide (trade name Enalapril comp), wherein enalapril is the ACE inhibitor and hydrochlorothiazide is the thiazide.
• Quinapril/hydrochlorothiazide (trade name Accuretic)^[2]
• Lisinopril/hydrochlorothiazide is marketed as Prinzide,^[3] Zestoretic,^[4] and many others.

• Perindopril/indapamide, a combination of an ACE inhibitor and a thiazide-like diuretic