AOC2

AOC2

AOC2

Protein

Amine oxidase, copper containing 2 (AOC2) is a protein that in humans is encoded by the AOC2 gene.[5] The protein is a copper-containing primary amine oxidase enzyme.

Quick Facts Identifiers, Aliases ...

Function

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000131480 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000078651 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: Amine oxidase, copper containing 2". Retrieved 2015-12-31.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Stub icon

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article AOC2, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.