ARIH2

ARIH2

ARIH2

Protein-coding gene in humans


Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene.[4][5]

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Function

ARIH2 influences development of Mll-Ell-induced acute myeloid leukemia and regulate the proliferation,[6] DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination,[7] ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.[8]


References

  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH (July 1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature". Protein Science. 8 (7): 1557–1561. doi:10.1110/ps.8.7.1557. PMC 2144383. PMID 10422847.
  4. Wang H, Bei L, Shah CA, Huang W, Platanias LC, Eklund EA (May 2018). "The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia". Oncogene. 37 (19): 2532–2544. doi:10.1038/s41388-018-0131-5. PMC 5945580. PMID 29459712.
  5. Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, et al. (November 2017). "ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages". Journal of Immunology. 199 (10): 3614–3622. doi:10.4049/jimmunol.1700184. PMID 29021376.

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