ARMCX6

ARMCX6

ARMCX6

Protein-coding gene in humans

Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.[5]

Quick Facts Identifiers, Aliases ...

It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

Protein sequence

     1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 
    41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 
    81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 
   121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 
   161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 
   201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 
   241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 
   301 FMSLFIRNGN REILLETPAP

Homology

ARMCX6 is conserved in many eukaryotic organisms.

Orthologs

taxonomic name common name NCBI entry Percentage of sequence similarity Length (AAs) comments
Homo sapiensHuman100%300armadillo repeat containing X-linked 6
Macaca mulattaRhesus monkey97.0%300PREDICTED: similar to amrmadillo repeat containing, X-linked 6 (H. sapiens)-like isoform 1
Equus caballusHorse90.0%300PREDICTED: similar to armadillo repeat containing, X-linked 6
Danio reriozebrafish84.0%301Similar to RIKEN cDNA 0610039K22
Mus musculusHouse Mouse97.7%393armadillo repeat containing, X-linked 6 (H. sapiens)-like
Bos tauruscow83.0%301armadillo repeat containing, X-linked 6
Mus musculusMouse82.0%301armadillo repeat containing, X-linked 6
Takifugu rubripesTetradontoidea66.0%818aryl hydrocarbon receptor 2C
Caenorhabditis elegansC. elegans50.0%332Serpentine Receptor, class H family member (srh-216)
Saccharomyces cerevisiaeYeast70.0%910Hul5p
Gallus gallusChicken52.0%317PREDICTED: hypothetical protein

Secondary Structure

The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below.[6][7]

                          10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
ARMCX6      231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277
1DW9_A       19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65
                 + +   ++ +  +  + + +   +   + +    +  +  ++++
Cyanase segment having identity with ARMCX6.

Expression

Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.[8][9][10]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000198960 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000050394 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: armadillo repeat containing".
  6. [6]
    SDSC Biology Workbench 2.0
  7. [7]
    "CBlast service is retiring".
  8. [8]
    EST Profile Viewer- Human
  9. [9]
    EST Profile Viewer- Mouse
  10. [10]
    Su AI, Wiltshire T, Batalov S, Lapp H, et al. (April 2004). "A gene atlas of the mouse and human protein-encoding transcriptomes". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 6062–7. Bibcode:2004PNAS..101.6062S. doi:10.1073/pnas.0400782101. PMC 395923. PMID 15075390.

Further reading


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