In suburban Cook County, Illinois, successful neurosurgeon Scott Harmon (Michael Chiklis) is on trial for providing material assistance to a school shooter. Scott's son Devin is suspended for threatening another student, and his father suspects that he is planning to commit an act of mass violence after finding a diary in his room filled with dark thoughts and fantasies of revenge. After a botched attempt to murder his son in a staged accident, Scott gives Devin money so he can travel and try to cope with his anger. Shortly after his return, Scott hears on the news that his son and a young man named Jasper are armed and have taken hostages at their former high school. When Scott tries to talk his son into surrendering, Devin angrily blames his father for giving up on him before committing suicide while Jasper is taken into custody. After hearing his story, the judge dismisses the charges against Scott.

In Cincinnati, deaf surrogate mother Ava (Stephanie Nogueras) is on trial for kidnapping and endangering a minor. Ava gives birth to baby Lucie for parents Jenny (Megan Boone) and Max (Aaron Ashmore), but not long after her birth they learn Lucie may also be deaf. Jenny and Max consider a cochlear implant procedure to allow Lucie to hear, but Ava is vehemently opposed to it. While Jenny and Max argue at their home, Ava takes Lucie and drives towards Michigan, as surrogacy adoption laws are different there. Her boyfriend KJ joins her, but she leaves him at a store while he’s in the bathroom. Ava decides to leave Lucie at a police station in Archbold, but she is arrested before she can do so. After replacing her original lawyer with a deaf consul (Lauren Ridloff), Ava tells her story to the court. Ultimately, Lucie's parents request the state drop the charges, and the prosecutor agrees to do so. Jenny and Max agree to try learning sign language.

In Nassau County, New York, teenager Danny is on trial for stabbing his stepmother Alison (Rachel Bilson). Shortly after his mother Isabel dies of an illness, Danny witnesses his father John (Jack Davenport) kissing Alison, Isabel's caretaker. Danny confronts his father, who tells him and his brother that he and Alison are in a relationship. Shortly after the family dog is struck and killed by a car, and Danny accuses Alison of killing it and his mother. Not long after that Danny is hospitalized after eating Alison's food, but no problems are found. John tells Danny his uncle had schizophrenia and he may have it as well. Danny collects oatmeal Alison made for him and tries to convince classmate Leanna to take it for chemical analysis, but she leaves after asking if he’s seen a therapist. That evening Danny grabs a knife and goes to Alison's room to gather evidence, but when confronted by her he stabs Alison before being arrested. Although initially refusing, Danny agrees to take a psychiatric evaluation and is sent to a mental facility. Six months later, Alison arrives and tells Danny his father died of a heart attack during their honeymoon, and that his brother has stomach pains.

In Cincinnati, Kendall Gomillion (Malcolm-Jamal Warner) is on trial for murder. After his daughter Ingrid is sexually assaulted at a park, Kendall wants to work with Detective Trent Douglas (Wendell Pierce), but his friend and coworker Lamar Mingoe encourages him to find the perpetrator himself. He informs Gomillion that Douglas looked away during the police killing of a black teenager. Lamar later tells Kendall he found the perpetrator at a park, so he and their coworker David Perry search for him while Kendall misses Ingrid’s catechism. They find and beat the man, Clyde Ellman, with Lamar ultimately killing him. Douglas visits Kendall and accuses him of involvement, but he claims he was at work with Lamar and David. Kendall eventually tells his wife Alisa (Karen LeBlanc) the truth, and she convinces him to tell Douglas his side of the story. But at the station, he learns his friends have pinned the blame solely on him. On trial, Kendall yells at Lamar while he testifies, calling him a liar. As bailiffs drag him away, Douglas tells Kendall he believes his story and that he will seek justice for him.

In Quincy, Massachusetts, drag queen Kevin Milstead/Robyn Blind (J. Harrison Ghee) is on trial for murder. After being catcalled while leaving a drag show, Robyn accepts a ride from the catcaller's brother Jamie Walsh, and they begin a relationship, but it ends after the second meeting where Jamie says his wife is dead. A month later they reconnect at Robyn's show, but later Robyn notices Jamie with a woman (Kristen Connolly). He goes to her store where he learns she is Jamie's wife Natalie and that Jamie was sexually abused by a man as a child. The conversation leads Natalie to suggest counseling to Jamie. Jamie realizes Robyn spoke to Natalie and confronts him, the two meeting at a park, where Natalie is watching. Later that day Jamie calls Robyn and says he and Natalie have split up and asks to leave with him. Robyn agrees, but at a river Jamie confesses he accidentally killed Natalie after an argument and that they need to hide the body. Robyn flees and encounters a passing motorist. At his trial, the case is leaning against Robyn until he returns in drag and explains how difficult it would to be to dispose of a body in that outfit. Robyn is acquitted of all charges.

Navajo Nation activist Naataanii Desmond and his friends Shandiin and Chase are on trial for murder. After being arrested while protesting a uranium mine, their friend Derrick (Kiowa Gordon) devises a plan to sabotage mining operations. He and Shandiin steal a keycard from a mine guard at a bar, but Derrick stays behind to speak to a man (Dash Mihok). The group breaks into the processing plant, but when Shandiin sees the man from the bar and FBI agents entering, the group attempts to escape. Derrick takes a guard hostage at gunpoint, but the group confronts him for being an informant. Following a standoff the group is arrested and the gun is dropped, but the lead agent shoots Derrick and plants the gun on him. During the trial the guard testifies that Derrick had the gun, and Chase confronts a Native American bailiff for covering his pro-Navajo shirt. The FBI agent tries to convince Naataanii to become an informant, but he refuses, and as he leaves the bailiff reveals to Naataanii she was recording the conversation. The activists are released, the DOJ closes the plant, and the FBI agent is charged for his role in the cover-up.

In Brooklyn, stand-up comedian Brenda (Whitney Cummings) is on trial for aggravated mayhem. After attending a stand-up routine Brenda and her best friend Chad (Baron Vaughn) visit a party hosted by their old friend Zeke Thompson, who has made it big as a comedian. After Chad leaves Brenda goes upstairs to show Zeke some material for his tour, but Zeke forcefully rapes her. The day after she has a rape kit taken, which leads to Zeke's arrest the next day. Brenda meets a woman named Tess (Mary Lynn Rajskub) who defends her online and in person, but Chad becomes suspicious after finding cut-outs of Zeke's face in her apartment. After the ADA interviews Zeke, Chad, and others, he drops charges against Zeke after finding it would be hard to convict him, as he had consensual sex with Brenda in the past. Tess, inspired by a comment Brenda left on one of Zeke's posts, confronts him outside a show and sets him on fire. At her trial, Brenda is confronted with the comment she left, but ultimately is found not guilty. Zeke, who survived his injuries, is confronted by a group of Brenda’s supporters as he leaves the courtroom, but Brenda tells them to let him go.

In Lake Forest, Illinois, Professor Laura Broder (Molly Parker) is on trial for murder. After her son Liam was killed in a school shooting (depicted in "Scott's Story"), Laura goes on the news to advocate for a gun bill. She learns of conspiracists who believe the shooting was a hoax, led by Joanna Lynn Pierce (Margo Martindale). After the family’s address is published, they go to a temporary home. Laura's husband Eric secretly buys a gun. When their other son Jonah is attacked while bicycling, Eric convinces Laura they should move. Laura and Jonah go for a drive but encounter a Joanna-led protest, leading Laura to grab her megaphone and get arrested. After Joanna files a restraining order, Laura argues with Eric over his gun purchase. They find the gun and Jonah missing and realize he found Joanna's address on the restraining order. They go to Joanna's house but find that Jonah has broken in and killed her. Laura calls 911 and claims she shot Joanna. At her trial, the defense attorney moves to have Jonah testify, but Laura opts to plead guilty instead, taking a minimum fifteen-year sentence.

In Lubbock County, Texas, schoolteacher Jack Fletcher (Jason Ritter) is on trial for statutory rape and transporting a minor across state lines. After discovering his student Clara Palmer attempting to hang herself, Jack intervenes and learns Clara is pregnant by her classmate Richie. Jack takes her to New Mexico to get an abortion, telling his fiancée Britney (Wrenn Schmidt) he's consulting a friend about a divorce. But Britney gets suspicious after finding beads in Jack's glovebox. After Jack learns from Richie that he has never had sex, he questions Clara and learns her stepfather has been sexually abusing her. Jack tells Britney the truth but is arrested before he can finish. Pressured by her stepfather, Clara testifies against Jack and says he was grooming her. Britney believes her until Jack texts her using his attorney's phone convincing her otherwise. Britney speaks to Clara's mother, who realizes the truth and confronts her husband, who is arrested. Clara recants her testimony and charges against Jack except transporting a minor are dropped, which Jack's attorney says will likely only result in probation and the loss of his teaching license in Texas.

In Brooklyn, Esme Barnes (Abigail Breslin) is on trial for murder. While out with her black girlfriend Aaliyah, Esme encounters a white supremacist rally that is interrupted by counterprotesters. A car then drives into the crowd. Esme finds Aaliyah pretending to be a white supremacist online to find the driver of the vehicle. After a white supremacist named Ancel shows up at their apartment, Esme, who is white, poses as a white supremacist and befriends the man. Esme learns his compound is planning something, but police decline to investigate. Esme accepts an invitation to the compound, where she finds the car and a Nazi flag but is discovered and attacked by their leader Shaggy, (Kyle Schmid), who also identifies himself as the driver of the car. Shaggy and Ancel argue over whether to kill Esme, leading to a fight, in which Ancel tells Esme to drive the car home. But when an officer opens the trunk a bomb goes off, killing six. The FBI raids the compound but finds it deserted. Esme leaves and tracks down the two white supremacists before running them down. Following her trial, which is briefly interrupted by militia members, Esme is found guilty.

In Sacramento, California, soccer coach Jiro Tamura (Ian Anthony Dale) is on trial for assault and negligence. After their mother dies, Jiro sends his brother Osamu to the Wildwood Gardens facility. While at the facility Jiro encounters aggressive resident Kyle "Kip" Tanner, who caretaker Leon says got into an altercation with Osamu. Osamu falls down some stairs, and he tells Jiro that a "bad man" pushed him. Jiro convinces his wife Sarah (Julia Chan) to look into Kip's criminal history, finding he was sent to Wildwood Gardens for an assault. The facility finds a tablet Kip stole from Osamu and has him sent to a different facility. A few days later Jiro is dropping off a bento for Osamu when he notices he has been tied to his bed. He brings Osamu home, shoving Leon unconscious along the way. At his home Jiro and Sarah speak to responding police officers when their daughters tell them Osamu has fallen into the pool, and although he falls unconscious Osamu survives. At his trial Jiro tells the jury he refused all plea deals because it would mean he would be ineligible to be Osamu's caretaker, and the jury votes to acquit.

In Manhattan, schoolteacher Morgan Knight (Meaghan Rath) is on trial for drug dealing. Morgan and her husband Jason (Christopher Gorham) have marital issues. After saving a student from choking, Morgan meets her coworker Kashir. Morgan later goes to his apartment and misses a planned train to Boston that crashes midway through. Not long after, Morgan files to divorce Jason and is granted full custody of their son Ari despite Jason's protests. Jason visits his police officer brother Eric and inquires about hiring a hitman, but Eric rejects the idea, leading Jason to plan for Morgan to be arrested. Morgan and Kashir are pulled over and a bag of cocaine is found in Ari's bag. Charges are dropped against Kashir but Morgan faces federal charges of drug dealing. Eric plants a fake witness in the trial, who says he bought drugs from Morgan, but her attorney goads him into saying he can't remember what her car was, despite it being an easily-recognizable yellow Porsche. The judge drops all charges and Eric is arrested. Some time later Morgan and Kashir are at a park with Ari. As he goes into some bushes to grab his frisbee, Ari is suddenly approached by Jason.

In Jersey City, New Jersey, limo driver Samir Khalil (Adam Bakri) is on trial for murder. Samir becomes infatuated with one of his passengers, real estate agent Alice Baylor (Julia Goldani Telles), who mistakenly leaves her phone in Samir's car. Samir is studying to become a doctor, but leaves the test and goes to his friend and coworker's home, telling his mom he's celebrating. He guesses Alice's phone password and connects with her while driving to her next stop based on the things she likes from her phone. He drops her off at a hospital, where he sees her boyfriend Joshua Donovan. Samir sits in his car outside Alice's house, where Josh mistakes him for a Lyft driver. Samir drives to his home and learns Joshua is married with children. He threatens to tell Alice. Samir goes to one of Alice's listings and they later go on a date, but after arriving home his mother confronts him for lying. Samir goes to Alice's house but finds she has reconnected with Josh, who has split from his wife. The two argue, leading Alice to leave both of them. Josh confronts Samir, who then runs him down. At his trial, Samir is found guilty of second-degree murder.

In Brooklyn, teenager Jessie is on trial for breaking and entering. After a genetic disorder forces her to quit running, Jessie asks her mother Kara (Betsy Brandt) about her father, who was a sperm donor, but Kara is resistant. After Jessie is caught taking a DNA kit, Kara gives her a sperm bank file that says her father died in a car accident. She is also opposed to her daughter being in a relationship with their neighbor Will. After failing to get info from the sperm bank by phone, Jessie steals a keycard while Will distracts the receptionist. They break in and find the files, but Will notices they appear different from the one Kara gave. After noticing they tripped an alarm the two flee, but Jessie's disorder forces her to stay and be arrested. Before the trial Kara talks to Will's father Donovan and informs him that he is Jessica's father. Will discovers this from Jessie's DNA kit, and he and his sister Fern confront their dad, who tells their mother Andrea (Natalie Brown) about the affair. Jessie is found guilty but receives a light sentence with no prison time. Kara tells Andrea they're thinking of moving, but she convinces her to stay.

In Lansing, Michigan, aging musician Billy Carlson (Keith Carradine) pleads guilty to manslaughter. After Billy's son Leo sets a fire after overdosing, he is sent to rehab. After Leo's release he is met with his more successful siblings Tommy and Ramona, the former of whom shows disdain for Leo. Billy is recording a greatest hits album, and Leo wishes to include one of his unpublished songs, but Billy disagrees. After hearing his parents arguing, Leo takes some of Billy's cancer medication and goes boating with his daughter Jo Jo, causing him to pass out and nearly crash. Billy and his wife Anne make the decision to take custody of Jo Jo, with Billy paying her drug-addicted mother Dana and her boyfriend to convince her to sign over custody. When Leo learns he's being sent back to rehab he demands to see Jo Jo, who is with Ramona. After leaving, Billy hears his unpublished song being played and realizes Leo is overdosing. Anne begins to administer narcan but hesitates and ultimately destroys the needle. When paramedics arrive, Billy takes responsibility, and the judge sentences him to four years in prison, which is likely a death sentence for him.