San Diego Padres

The San Diego Padres selected Cimber in the ninth round of the 2013 Major League Baseball draft.^[4][5] He signed and spent 2013 with the Eugene Emeralds where he was 3–1 with a 2.56 ERA in 28 relief appearances. In 2014, he played for the Lake Elsinore Storm where he pitched to a 5–3 record, 2.90 ERA, and 1.15 walks plus hits per inning pitched (WHIP) in 52 games, and in 2015, he pitched for both the San Antonio Missions and El Paso Chihuahuas where he posted a combined 4–2 record and 3.05 ERA in 46 total games between both teams. Cimber spent 2016 with both San Antonio and El Paso where he was 3–3 with a 3.77 ERA in 46 games and 2017 with the same two teams, going 5–2 with a 2.90 ERA with an 0.90 WHIP in 80+2⁄3 innings pitched.^[6]

Cimber made the San Diego's Opening Day roster in 2018. He made his major league debut on March 29.^{[citation needed]}

Cleveland Indians

On July 19, 2018, the Padres traded Cimber and Brad Hand to the Cleveland Indians for Francisco Mejía.^[7] He finished his 2018 season with a 3–8 record and a 3.42 ERA in seventy relief appearances, and shared the major league lead in intentional walks, with nine, while he had a total of only 17 walks.^[8]

With the 2020 Cleveland Indians, Cimber appeared in 14 games, compiling a 0–1 record with 3.97 ERA and five strikeouts in 11+1⁄3 innings pitched.^[9] Cimber was designated for assignment on November 25, 2020.^[10]

Miami Marlins

On November 30, 2020, the Indians traded Cimber to the Miami Marlins in exchange for cash considerations.^[11] In 33 appearances with Miami in 2021, Cimber pitched to a 2.88 ERA with 21 strikeouts in 34.1 innings of work.

Toronto Blue Jays

On June 29, 2021, Cimber was traded to the Toronto Blue Jays alongside Corey Dickerson in exchange for Joe Panik and minor league pitcher Andrew McInvale.^[12] Cimber made 39 appearances in 2021 for the Blue Jays, going 2–2 with a 1.69 ERA and 30 strikeouts.

On March 22, 2022, Cimber signed a $1.575 million contract with the Blue Jays, avoiding salary arbitration.^[13] On the year, he made a league–leading 77 appearances, and posted a 10–6 record and 2.80 ERA with 58 strikeouts and 4 saves in 70+2⁄3 innings of work.

In 2023, Cimber began the year out of Toronto's bullpen, but uncharacteristically struggled to a 7.40 ERA in 20+2⁄3 innings across 22 games. On June 24, 2023, he was placed on the injured list with a right shoulder impingement.^[14] He was transferred to the 60–day injured list on July 19.^[15] He was non-tendered and became a free agent on November 17.

Los Angeles Angels

On December 13, 2023, Cimber signed a one-year, $1.65 million contract with the Los Angeles Angels.^[16]