Alkylglycerone_phosphate_synthase

Alkylglycerone phosphate synthase

Alkylglycerone phosphate synthase

Class of enzymes

Alkylglycerone phosphate synthase (EC 2.5.1.26, alkyldihydroxyacetonephosphate synthase, alkyldihydroxyacetone phosphate synthetase, alkyl DHAP synthetase, alkyl-DHAP, dihydroxyacetone-phosphate acyltransferase, DHAP-AT) is an enzyme associated with Type 3 Rhizomelic chondrodysplasia punctata.[1][2] This enzyme catalyses the following chemical reaction

1-acyl-glycerone 3-phosphate + a long-chain alcohol an alkyl-glycerone 3-phosphate + a long-chain acid anion
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References

  1. [1]
    Brown AJ, Snyder F (August 1982). "Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism". The Journal of Biological Chemistry. 257 (15): 8835–9. doi:10.1016/S0021-9258(18)34205-4. PMID 7096336.
  2. [2]
    Wykle RL, Plantadosi C, Snyder F (May 1972). "The role of acyldihydroxyacetone phosphate, reduced nicotinamide adenine dinucleotide, and reduced nicotinamide adenine dinucleotide phosphate in the biosynthesis of O-alkyl glycerolipids by microsomal enzymes of Ehrlich ascites tumor". The Journal of Biological Chemistry. 247 (9): 2944–8. doi:10.1016/S0021-9258(19)45301-5. PMID 4401994.


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