Alpha-1B-adrenergic_receptor

Alpha-1B adrenergic receptor

Alpha-1B adrenergic receptor

Protein-coding gene in the species Homo sapiens

The alpha-1B adrenergic receptor (α1B-adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[5] The crystal structure of the α1B-adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.[6]

Quick Facts ADRA1B, Identifiers ...

Receptor

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.[5]

Ligands

Antagonists

Interactions

Alpha-1B adrenergic receptor has been shown to interact with AP2M1.[8] A role in regulation of dopaminergic neurotransmission has also been suggested.[9][10]

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000170214 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000050541 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: ADRA1B adrenergic, alpha-1B-, receptor".
  6. [6]
    Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PR, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A (January 2022). "Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition". Nature Communications. 13 (1): 382. Bibcode:2022NatCo..13..382D. doi:10.1038/s41467-021-27911-3. PMC 8770593. PMID 35046410.
  7. [7]
    Mizusawa H, Hedlund P, Sjunnesson J, Brioni JD, Sullivan JP, Andersson KE (2002). "Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist". Br. J. Pharmacol. 136 (5): 701–8. doi:10.1038/sj.bjp.0704773. PMC 1573401. PMID 12086979.
  8. [8]
    Diviani D, Lattion AL, Abuin L, Staub O, Cotecchia S (May 2003). "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". J. Biol. Chem. 278 (21): 19331–40. doi:10.1074/jbc.M302110200. PMID 12644451.
  9. [9]
    Drouin C, Darracq L, Trovero F, Blanc G, Glowinski J, Cotecchia S, Tassin JP (April 2002). "Alpha1b-adrenergic receptors control locomotor and rewarding effects of psychostimulants and opiates". J. Neurosci. 22 (7): 2873–84. doi:10.1523/jneurosci.22-07-02873.2002. PMC 6758308. PMID 11923452.
  10. [10]
    Auclair A, Drouin C, Cotecchia S, Glowinski J, Tassin JP (December 2004). "5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants". Eur. J. Neurosci. 20 (11): 3073–84. doi:10.1111/j.1460-9568.2004.03805.x. PMID 15579162. S2CID 25138763.

Further reading


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