Anime Milwaukee (AMKE) is an annual three-day anime convention held during February at the Baird Center and Hilton Milwaukee City Center in Milwaukee, Wisconsin.^[4] It is Wisconsin's largest anime convention.^[5]

The convention typically offers anime music videos, an art contest, artist alley, charity ball, cosplay chess, a dealer's room, fashion show, maid cafe, manga library, masquerade, movies, rave, tabletop gaming, and video game tournaments.^{[4][6][7][8][9]} The convention runs for 24 hours a day.^[10]

The 2017 charity ball benefited the Milwaukee LGBT Community Center.^[9]

Anime Milwaukee began in 2007 and was founded by the Japanese Animation Association at the University of Wisconsin-Milwaukee.^[7] In 2011, the convention moved to the Hyatt Regency Milwaukee & Frontier Airlines Center in Milwaukee, which allowed for 24-hour programming.^[7] Attendees who preregistered for Anime Milwaukee in 2013 could receive a discount for the Distant Worlds concert held the day before the convention on February 14, 2013.^[11] The convention shared space in 2014 at the Wisconsin Center with Pheasant Fest, a hunting convention.^[12] The combined conventions economic impact were expected to be $1.5 million.

In 2015, Anime Milwaukee's expected economic impact was over $1 million and it shared Wisconsin Center space with the Midwest Twisters Gymnastics Invitational.^[10][13] The convention brought $1.2 million to the local economy in 2016.^[14][15] Anime Milwaukee in 2017 occupied all the floors of the Wisconsin Center to expand panels and video gaming.^[14] The convention was estimated to bring $2.5–3 million to the local economy.^[9][16] Anime Milwaukee was estimated to bring $4 million to the local economy in 2019.^[17] Anime Milwaukee 2021 was cancelled due to the COVID-19 pandemic.^[18][19] Anime Milwaukee had COVID-19 policies in 2022 that included mandatory masks, with ether vaccination or a negative test.^[20]