Anna Balakian was born in Constantinople to Armenian parents. At the age of 11, she moved with her family to New Britain, Connecticut. She earned her bachelor's degree at Hunter College and her master's and doctorate degree at Columbia University. While in graduate school, she taught French literature and language full-time at the Hunter College High School.
She published her first book, The Literary Origins of Surrealism in 1947. In this study about the founders of modern French poetry, Anna Balakian placed avant-garde writers and artists against the background of French and German romanticism. In 1953, she began her long career at New York University culminating in her eight-year chairmanship of the Department of Comparative Literature. Balakian's next book, Surrealism: The Road to the Absolute (1959), is an exposition of, and apologia for, surrealist literature and art. In The Symbolist Movement: A Critical Appraisal (1969), she gives a concise yet detailed account of symbolist poetry. Her André Breton: Magus of Surrealism (1971) was the first full-scale biography of the founder of the surrealist movement.
She and her sister, Nona Balakian, a literary critic and an editor at The New York Times Book Review,[1] were members of a literary circle that also included the playwright William Saroyan and the diarist Anaïs Nin.
In 2004, the International Comparative Literature Association established the Anna Balakian Prize in honor of her and to promote scholarly research by younger comparatists.[2]