Antequera-Santa Ana railway station is a railway station at a railway junction near the Spanish town of Antequera, Málaga in Andalusia. It is located 17 kilometres (11 mi) from the town centre.^[2] It was created principally to serve passengers on the developing AVE high-speed rail system. However, the station has access to Iberian gauge lines for conventional services.

It serves passengers using the Madrid–Málaga high-speed rail line and the Antequera-Granada high-speed rail line.

A gauge changer exists near the station, allowing trains to operate seamlessly on both standard gauge AVE tracks and Iberian gauge tracks.^[3] Antequera-Santa Ana is served by Media Distancia trains to Algeciras, Almería and Seville-Santa Justa.

The station was opened in 2006, originally as a terminus on the then-incomplete Córdoba–Málaga branch of the Spanish AVE high-speed rail system. The AVE reached Málaga in 2007. In 2019, the Antequera–Granada high-speed rail line opened, providing AVE service to Granada.^[4] Also in 2019, Adif began works to improve the lighting surrounding the station at a cost of €38,000.^[5]